The reduction of proprioceptors in the mesencephalic trigeminal tract nucleus after neonatal masseteric nerve transection; effect of brain-derived neurotrophic factor
| Autor: | H.W. Jin, Hiroyuki Ichikawa, S. Terayama, Tomoichiro Yamaai, Saburo Matsuo, Tomosada Sugimoto |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Nervous system Time Factors medicine.medical_treatment Central nervous system Cell Count Sensory receptor Trigeminal Nuclei Functional Laterality Neurotrophic factors medicine Animals Molecular Biology Neurons Brain-derived neurotrophic factor Proprioception Masseter Muscle business.industry Brain-Derived Neurotrophic Factor General Neuroscience Peripheral Nervous System Diseases Axotomy Masseteric nerve Anatomy Rats Parvalbumins medicine.anatomical_structure Animals Newborn Female Neurology (clinical) business Developmental Biology |
| Zdroj: | Brain Research. 1153:98-102 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2007.03.060 |
| Popis: | The effect of neonatal masseteric nerve transection on primary proprioceptors was examined in the mesencephalic trigeminal tract nucleus (Mes5) of the rat. At 72 h to 21 days after the injury, the number of Mes5 neurons decreased on the side ipsilateral to the transection. The means ± SD of percentage proportion of ipsilateral/contralateral neurons at 72 h and 21 days were 69.9 ± 7.5% and 58.2 ± 14.6%, respectively. The application of brain-derived neurotrophic factor to the proximal stump of the masseteric nerve delayed the loss of Mes5 neurons at 72 h after the injury; the mean numbers ± SD of ipsilateral and contralateral Mes5 neurons in injured animals with BDNF application was 553.6 ± 61.9 and 558.4 ± 55.3, respectively. Saline application had no effect on the injury-induced loss of Mes5 neurons; i.e., the mean numbers ± SD of ipsilateral and contralateral Mes5 neurons were 367.3 ± 72.5 and 543 ± 33.5, respectively. These findings indicate that trigeminal primary proprioceptors are sensitive to the neonatal injury. The survival of proprioceptors during early postnatal period is probably dependent upon brain-derived neurotrophic factor in the trigeminal nervous system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect