Destruction mechanisms of ozone over SARS-CoV-2
| Autor: | Seyed Jalal Kiani, Angila Ataei-Pirkooh, Bita Mehravi, Kowsar Bagherzadeh, Mehran Kianirad, Alireza Ghasempour, Omid Pourdakan, Reza Adl, Ali Alavi, Mehdi Mirzaei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oropharyngeal swab
Time Factors Ozone Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Science Coronavirus Papain-Like Proteases Protein Structure Secondary Virus Microbiology chemistry.chemical_compound Microscopy Electron Transmission Virus morphology medicine Humans Viral Regulatory and Accessory Proteins chemistry.chemical_classification Coronavirus RNA-Dependent RNA Polymerase Multidisciplinary SARS-CoV-2 Protein Structure Tertiary COVID-19 Drug Treatment Amino acid Zinc Mechanism of action chemistry Viral Envelope Sputum Medicine medicine.symptom |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | In this pandemic SARS-CoV-2 crisis, any attempt to contain and eliminate the virus will also stop its spread and consequently decrease the risk of severe illness and death. While ozone treatment has been suggested as an effective disinfection process, no precise mechanism of action has been previously reported. This study aimed to further investigate the effect of ozone treatment on SARS-CoV-2. Therefore, virus collected from nasopharyngeal and oropharyngeal swab and sputum samples from symptomatic patients was exposed to ozone for different exposure times. The virus morphology and structure were monitored and analyzed through Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), Atomic Absorption Spectroscopy (AAS), and ATR-FTIR. The obtained results showed that ozone treatment not only unsettles the virus morphology but also alters the virus proteins’ structure and conformation through amino acid disturbance and Zn ion release from the virus non-structural proteins. These results could provide a clearer pathway for virus elimination and therapeutics preparation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|