The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children
| Autor: | Du Young Choi, Dong Sup Kim, Se Hoon Yoon, Sae Ron Shin, Seung Taek Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Transferrin receptor Pediatrics Total iron-binding capacity Internal medicine Medicine Child Mean corpuscular volume Soluble transferrin receptor medicine.diagnostic_test biology business.industry Transferrin saturation lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Ferritin Endocrinology Iron-deficiency anemia Iron deficiency anemia Pediatrics Perinatology and Child Health Immunology Serum iron biology.protein Original Article business |
| Zdroj: | Korean Journal of Pediatrics, Vol 58, Iss 1, Pp 15-19 (2015) Korean Journal of Pediatrics |
| ISSN: | 2092-7258 1738-1061 |
| Popis: | Purpose: Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis. Concentrations of serum sTfR are related to iron status and erythropoiesis in the body. We investigated whether serum sTfR levels can aid in diagnosis and treatment of iron deficiency anemia (IDA) in children. Methods: Ninety-eight patients with IDA were enrolled and were classified according to age at diagnosis. Group 1 comprised 78 children, aged 6–59 months, and group 2 comprised 20 adolescents, aged 12–16 years. Results: In group 1, patients’ serum sTfR levels correlated negatively with mean corpuscular volume; hemoglobin (Hb), ferritin, and serum iron levels; and transferrin saturation and positively with total iron binding capacity (TIBC) and red cell distribution width. In group 2, patients’ serum sTfR levels did not correlate with ferritin levels and TIBC, but had a significant relationship with other iron indices. Hb and serum sTfR levels had a significant inverse relationship in both groups; however, in group 1, there was no correlation between Hb and serum ferritin levels. In 30 patients of group 1, serum sTfR levels were significantly decreased with an increase in Hb levels after iron supplementation for 1 month. Conclusion: Serum sTfR levels significantly correlated with other diagnostic iron parameters of IDA and inversely correlated with an increase in Hb levels following iron supplementation. Therefore, serum sTfR levels can be a useful marker for the diagnosis and treatment of IDA in children. |
| Databáze: | OpenAIRE |
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