Anesthetics disrupt brain development via actions on the mTOR pathway
| Autor: | Jing Xu, C. David Mintz, Eunchai Kang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell signaling anesthesia Hippocampal formation 03 medical and health sciences 0302 clinical medicine neurotoxicity cell signaling Medicine lcsh:QH301-705.5 PI3K/AKT/mTOR pathway business.industry Dentate gyrus Neurogenesis Neurotoxicity Cognition medicine.disease Article Addendum neurogenesis 030104 developmental biology lcsh:Biology (General) Anesthetic mTOR General Agricultural and Biological Sciences business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Communicative & Integrative Biology Communicative & Integrative Biology, Vol 11, Iss 2, Pp 1-4 (2018) |
| ISSN: | 1942-0889 |
| DOI: | 10.1080/19420889.2018.1451719 |
| Popis: | Experiments conducted in non-human primates have recently provided new evidence supporting a longstanding concern that exposure to general anesthesia during late intrauterine life or early childhood can cause lasting cognitive deficits through harmful effects on brain development. The mammalian target of rapamycin (mTOR) signaling system plays a key role in both normal brain development and in a wide range of developmental disorders that are characterized by cognitive deficits. Intriguingly, our recently published work shows that anesthetics can chronically alter mTOR signaling in the hippocampal dentate gyrus and that normalization of mTOR signaling can prevent anesthesia-induced perturbation of structure and function. In this addendum, we briefly discuss the putative role of mTOR in developmental anesthetic neurotoxicity. |
| Databáze: | OpenAIRE |
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