Multidimensional Aspects of Female Sexual Function in Congenital Adrenal Hyperplasia: A Case-Control Study
| Autor: | Deborah P. Merke, Maggie Dwiggins, Kylie Fowler, Brittany Brookner, Veronica Gomez-Lobo, Padmasree Veeraraghavan |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Obstetrics business.industry Endocrinology Diabetes and Metabolism Virilization Pelvic pain 030232 urology & nephrology 030209 endocrinology & metabolism Context (language use) medicine.disease 03 medical and health sciences 0302 clinical medicine Sexual dysfunction Quality of life medicine Congenital adrenal hyperplasia medicine.symptom Sexual function business Body mass index Clinical Research Articles |
| Zdroj: | J Endocr Soc |
| ISSN: | 2472-1972 |
| Popis: | Context 46,XX patients with classic congenital adrenal hyperplasia (CAH) are exposed to elevated androgens in utero causing varying levels of virilization. The majority undergo feminizing genitoplasty early in life, with potential impact on sexual function and health-related quality of life (HRQoL). Objective We aimed to determine how sexual and lower urinary tract function, body image, and global HRQoL differs between patients with classic CAH and controls and to characterize how gynecologic anatomy contributes to outcomes. Methods 36 patients with classic CAH and 27 control women who were matched for age, race, and marital status underwent standardized gynecological examination and validated questionnaires. The responses were analyzed in relation to gynecological measurements, genotype, and disease status. Results Compared with controls, patients with CAH were more likely to have sexual dysfunction (P = 0.009), dyspareunia (P = 0.007), and other pelvic pain (P = 0.007); were less likely to be heterosexual (P = 0.013) or ever have been sexually active (P = 0.003); had poorer body image independent of body mass index (P Conclusions 46,XX patients with CAH have increased rates of sexual dysfunction, poor body image, and poor HRQoL, which is mitigated by having a larger vaginal caliber. Management aimed at optimizing vaginal caliber might improve sexual function. |
| Databáze: | OpenAIRE |
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