LOSS OF CAPACITY TO ELEVATE PLASMA CORTISOL IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) TREATED WITH A SINGLE INJECTION OF o,p′-DICHLORODIPHENYLDICHLOROETHANE

Autor:	Sandrine, Benguira, Vincent S, Leblond, Jean-Philippe, Weber, Alice, Hontela
Rok vydání:	2002
Předmět:	Antineoplastic Agents Hormonal Hematocrit Hydrocortisone Liver Oncorhynchus mykiss Health Toxicology and Mutagenesis Adrenal Glands Body Weight Animals Environmental Chemistry Mitotane Glycogen Injections Intraperitoneal
Zdroj:	Environmental Toxicology and Chemistry. 21:1753
ISSN:	1552-8618 0730-7268
DOI:	10.1897/1551-5028(2002)021<1753:loctep>2.0.co;2
Popis:	The organochlorine o,p'- dichlorodiphenyldichloroethane (o,p'-DDD) is a metabolite of dichlorodiphenyltrichloroethane (DDT), known for its adrenolytic actions in birds and mammals. The effects of o,p'-DDD on the cortisol stress response were investigated in rainbow trout, Oncorhynchus mykiss, in a dose-response study in vivo. A dose-dependent decrease in plasma cortisol levels was observed on days 7 and 14 after a single i.p. injection of o,p'-DDD. Treatment with o,p'-DDD had no effect on weight gain, hematocrit, and gonado- or hepatosomatic index but decreased liver glycogen reserves. The results indicate that o,p'-DDD is an adrenotoxic compound in rainbow trout and that its effects can be detected even 14 d postinjection.
Databáze:	OpenAIRE
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