Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
| Autor: | Fabrizio Stocchi, Raffaele Ferri, Virginia Cipollini, Görsev Yener, Moira Marizzoni, Bahar Güntekin, Francesco Famà, Tuba Aktürk, Andrea Soricelli, Claudio Babiloni, Dario Arnaldi, Franco Giubilei, Claudio Del Percio, Roberta Lizio, Laura Vacca, Francesco Orzi, Giuseppe Noce, Susanna Lopez, Flavio Nobili, Lutfu Hanoglu, Giovanni B. Frisoni, Derya Durusu Emek-Savaş, Carla Buttinelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Alzheimer's disease dementia (ADD) delta rhythms exact low resolution brain electromagnetic source tomography (eLORETA) resting state electroencephalographic (rsEEG) rhythms Delta rhythms Exact low resolution brain electromagnetic source tomography (eLORETA) Resting state electroencephalographic (rsEEG) rhythms Cerebral Cortex Delta Rhythm Electroencephalography Humans Rest Wakefulness Alzheimer Disease Audiology 050105 experimental psychology Arousal 03 medical and health sciences 0302 clinical medicine Physiology (medical) Medicine Dementia 0501 psychology and cognitive sciences Donepezil medicine.diagnostic_test Resting state fMRI business.industry General Neuroscience 05 social sciences medicine.disease Neuropsychology and Physiological Psychology Alzheimer's disease business 030217 neurology & neurosurgery medicine.drug |
| Popis: | Extending Basar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization of alpha rhythms in normal (Nold) seniors with some derangement in Alzheimer's disease dementia (ADD).Clinical and EEG datasets in 100 ADD and 100 Nold individuals matched as demography, education, and gender were taken from an international archive. Standard delta (< 4 Hz) and alpha1 (8-10.5 Hz) bands were used for the main analysis, while alpha2 (10.5-13 Hz), theta (4-8 Hz), beta1 (13-20 Hz), beta2 (20-35 Hz), and gamma (35-40 Hz) served as controls. In the interpretation, the higher the alpha1 power (density), the lower that arousal. As expected, when compared to the Nold group, the ADD group showed higher global (scalp) power density at the delta-theta band and lower global power density at the alpha-beta bands. As novel findings, we observed that: (1) in the Nold group, the global delta and alpha1-2 power were negatively and linearly correlated; (2) in the ADD group, this correlation was just marginal; and (3) in both Nold and AD groups, the EEG epochs with the highest delta power (median value for stratification) were associated with the lowest global alpha1 power. This effect was related to eLORETA freeware solutions showing maximum alpha1 source activations in posterior cortical regions.These results suggest that even in quiet wakefulness, delta and alpha rhythms are related to each other, and ADD partially affects this cross-band neurophysiological mechanism. Ministry of Health, Italy ; Ministry of Health Italy - Ricerca Corrente (MOH-RC) ; H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" ; H2020-TWINN-2015 project with the short title "SynaNet" |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|