Interstitial concentration of antibiotics and their significance for an adequate dosage
| Autor: | H. U. Eickenberg |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Microbiology (medical)
Cefotaxime medicine.drug_class business.industry Antibiotics Cefazolin Area under the curve General Medicine Anti-Bacterial Agents Cephalosporins Kinetics Dogs Infectious Diseases Pharmacokinetics Anesthesia medicine Animals Tissue Distribution Cefamandole Cephradine business Cefuroxime medicine.drug |
| Zdroj: | Infection. 8:S39-S44 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/bf01644934 |
| Popis: | The pharmacokinetic characteristics of the parenteral cephalosporins, cephalothin, cefazolin, cephradine, cefamandole, cefuroxime and cefotaxime (HR-756) were compared applying six different pharmacokinetic points of view. In interpreting antibiotic concentrations measured in soft tissue interstitial fluid (STIF), special attention was paid to the following parameters: cross-point; serum to STIF (AUC) ratio before and after cross-point; STIF half-life time (T 1/2); half-life time area under the curve (AUC) correlated to total STIF area as a percentage and total STIF area under the curve (AUC) measured in micrograms per four hours. The test substances were given to dogs as a single-dose intravenous bolus injection of 20 microgram/kg bodyweight. The investigations resulted in a different order of precedence according to the pharmacokinetic viewpoint applied. Pharmacokinetic parameters are discussed on the basis of the results of this study indicating a more rational antibiotic treatment regimen which is very important in the perioperative prophylaxis of wound infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink