Polymorphism in the ADRB2 gene explains a small portion of intersubject variability in pain relative to cervical dilation in the first stage of labor
| Autor: | Pamela Flood, William M. Jackson, Abdullah Sulieman Terkawi, Rabeena Tabassum, Shehnaz Hansoti |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Cervical dilation Saudi Arabia Pain Cervix Uteri Oxytocin Polymorphism Single Nucleotide Young Adult Pregnancy Internal medicine Artificial rupture of membranes Oxytocics medicine Anesthesia Obstetrical Humans Young adult Risk factor Pain Measurement Models Statistical Polymorphism Genetic business.industry Chronic pain Age Factors Labor pain DNA medicine.disease Delivery Obstetric Oxytocin receptor Anesthesiology and Pain Medicine Socioeconomic Factors Anesthesia Analgesia Obstetrical Female Receptors Adrenergic beta-2 business Labor Stage First |
| Zdroj: | Anesthesiology. 121(1) |
| ISSN: | 1528-1175 |
| Popis: | Background: Variability in labor pain has been associated with demographic, clinical, and psychological factors. Polymorphisms of the β2-adrenergic receptor gene (ADRB2) influence sensitivity to experimental pain in humans and are a risk factor for chronic pain. The authors hypothesized that polymorphisms in ADRB2 may influence labor pain. Methods: After Institutional Review Board approval and written informed consent, the authors prospectively obtained hourly pain reports from 233 nulliparous parturients during the first stage of labor, of which 199 were included in the current analysis. DNA from blood samples was genotyped at polymorphisms in the genes for the β2-adrenergic receptor, the μ opioid receptor subtype 1, catechol-O-methyltransferase, fatty acid amide hydrolase, and the oxytocin receptor. Labor pain as a function of cervical dilation was modeled with previously described methods. Patient covariates, ADRB2 genotype, and obstetrical and anesthesia treatment were evaluated as covariates in the model. Results: Labor pain more rapidly became severe in parturients heterozygous or homozygous for the G allele at rs1042714 in the ADRB2 gene. Labor pain increased more rapidly after artificial rupture of membranes, augmentation with oxytocin, and in younger women. Inclusion of covariates explained approximately 10% of the variability between subjects. ADRB2 genotype explained less than 1% of the intersubject variability. Conclusion: ADRB2 genotype correlates with labor pain but explained less than 1% of the intersubject variance in the model. |
| Databáze: | OpenAIRE |
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