Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man
| Autor: | Fauzia Moyeen, Khaled H. Aburisheh, Yousuf Al Farsi, Faryal Mehmood |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Leukopenia Diabetic ketoacidosis business.industry medicine.medical_treatment Insulin lcsh:R lcsh:Medicine Hydroxychloroquine Case Report General Medicine medicine.disease Gastroenterology Arabs Insulin resistance Mixed connective tissue disease Internal medicine medicine Plasmapheresis medicine.symptom Insulin Resistance business Acanthosis nigricans medicine.drug Mixed Connective Tissue Disease |
| Zdroj: | Oman Medical Journal Oman Medical Journal, Vol 35, Iss 3, Pp e134-e134 (2020) |
| ISSN: | 2070-5204 1999-768X |
| Popis: | Type B insulin resistance syndrome (TBIRS) has not been previously reported in Arab populations. We report a case of TBIRS in an Arab patient with mixed connective tissue disease (MCTD). Investigations revealed a clinical condition marked by positive anti-insulin receptor and ribonucleoprotein antibodies. The patient presented with severe hyperglycemia, weight loss, arthralgia, and acanthosis nigricans. He was managed successfully with an intensive pulsed combination regimen of cyclophosphamide and plasmapheresis augmented with high doses of prednisolone, which normalized his blood sugar levels without insulin therapy. MCTD was controlled by hydroxychloroquine. During the course of his treatment, the patient developed diabetic ketoacidosis secondary to the gluteal abscess, leukopenia, and recurrent hypoglycemia. Here, we showed that immunosuppressive agents and plasmapheresis can induce remission of TBIRS and can be used to normalize the blood sugar levels of Arab patients with this condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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