Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi
| Autor: | Ying-Hong Liu, Yue-Juan Pei, Dong-Qing Fei, Zhan-Xin Zhang, Feng-Ming Qi, Qiao-Ling Hu, Pei-Qian Wu |
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| Rok vydání: | 2017 |
| Předmět: |
Staphylococcus aureus
Iridoid medicine.drug_class Stereochemistry Microbial Sensitivity Tests Biology 01 natural sciences Plant Roots Mice Valerian Cell Line Tumor Drug Discovery medicine Animals Humans MTT assay Iridoids Pharmacology Molecular Structure 010405 organic chemistry Absolute configuration General Medicine biology.organism_classification In vitro 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Pseudomonas aeruginosa Epimer Antibacterial activity Two-dimensional nuclear magnetic resonance spectroscopy Sesquiterpenes Bacteria |
| Zdroj: | Fitoterapia. 123 |
| ISSN: | 1873-6971 |
| Popis: | Three new iridoids, valejatanins A-C (1-3), and one new natrual iridoid (4), together with four known sesquiterpenoids (5-8), were isolated from the roots of Valeriana jatamansi Jones. Compounds 3 and 4 are C(4)-epimers. Their structures were elucidated by extensive spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. The absolute configuration of 5 was determined for the first time by single-crystal X-ray diffraction analysis with Cu-Kα irradiation. The cytotoxic activities of all compounds were evaluated against HT29, K562 and B16 cancer cell lines in vitro by MTT assay. Valejatanin A (1) showed noteworthy cytotoxic activities with IC50 values of 22.17, 15.26, 3.53μg/mL against three cancer cell lines. The antibacterial activities of all compounds against bacteria were tested in vitro. Compound 6 exhibited antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa. |
| Databáze: | OpenAIRE |
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