The Effect of Gabapentin on Postoperative Pain, Morphine Sparing Effect and Preoperative Anxiety in Patients Going for Sleeve Gastrectomy Surgical Procedure
Autor: | Fahad Bamehriz, Mueen Ullah Khan, Awatif Fadin, Rashid Saeed Khokhar, Mansoor Aqil, Fatama Al Dammas |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male Sleeve gastrectomy Gabapentin Adolescent Sedation medicine.medical_treatment Saudi Arabia Anxiety Placebo Preoperative care law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method 030202 anesthesiology law Gastrectomy Preoperative Care medicine Humans 030223 otorhinolaryngology Pain Measurement Analgesics business.industry General Medicine Middle Aged Obesity Morbid Analgesics Opioid Anti-Anxiety Agents Anesthesia Morphine Female Laparoscopy medicine.symptom business medicine.drug |
Zdroj: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 29(8) |
ISSN: | 1681-7168 |
Popis: | Objective To determine the effectiveness of preoperative administration of gabapentin in reduction of acute postoperative pain, morphine consumption and preoperative anxiety and sedation in obese patients undergoing laparoscopic sleeve gastrectomy. Study design Double-blinded randomised control trial. Place and duration of study King Khalid University Hospital, King Saud University Riyadh, Saudi Arabia, from July 2014 to January 2017. Methodology Fifty patients undergoing sleeve gastrectomy were enrolled in the study. The subjects received either 1200 mg gabapentin or placebo 2 hours before surgery. The amount of morphine consumption and postoperative pain at 4, 8,12,16, 20 and 24 hours of surgery were measured. Preoperative anxiety and sedation were recorded at 2 hours interval after the drug administration. Results There was no significant difference in patient characteristics in both groups. 24 hours PCA morphine consumption was significantly lower in gabapentin group than in the placebo group, 15.08±4.55 vs. 27.80±2.51 (p=0.001). Preoperative VAS anxiety, pre- verses post-drug, was significantly lower in gabapentin group 5.80±1.11 vs. 3.52±1.00 (p=0.001) than in placebo group 6.08 1.28 vs. 6.28 1.24 (p=0.635). Preoperative sedation score was not different in both groups. Conclusion Preoperative oral gabapentin was effective in reducing the postoperative pain, morphine consumption and preoperative anxiety in morbid obese patients undergone laparoscopic sleeve gastrectomy. |
Databáze: | OpenAIRE |
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