HLA-B15 association with erythema multiforme
| Autor: | Eleanor Ciftan, Deborah V. Dawson, Madeleine Duvic, Emily G. Reisner |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Erythema Multiforme
MHC class II medicine.medical_specialty biology business.industry Genes MHC Class II Dermatology Disease Human leukocyte antigen HLA-B15 Antigen medicine.disease Immune system Antigen HLA Antigens HLA-B Antigens Immunology biology.protein medicine Humans Erythema multiforme business Prospective cohort study |
| Zdroj: | Journal of the American Academy of Dermatology. 8:493-496 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/s0190-9622(83)70054-x |
| Popis: | Erythema multiforme (EM) is a cutaneous reaction pattern which follows numerous infections, drugs, neoplastic and inflammatory disorders in some individuals. We undertook a prospective study of thirty-eight HLA specificities of the -A, -B, and -C series in 16 Caucasian patients with EM and in 140 local Caucasian controls. Seven of 16 patients (44%) with EM and 5 of 9 patients (55%) with EM following herpes simplex infections possessed the HLA-B15 antigen, compared to 7% of local controls and 11.6% of the 1980 WHO Workshop Caucasian controls. Both associations were highly significant (p = 0.0125 and p = 0.02) when corrected for 38 HLA antigens. This is the first reported HLA association for erythema multiforme, a disease which may be a host-specific immune response to various antigens, determined in part by genes linked to HLA-B15. |
| Databáze: | OpenAIRE |
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