Before platelets: the production of platelet-activating factor during growth and stress in a basal marine organism
| Autor: | Kevin Green, Louis-Félix Nothias, Steven D. Quistad, Forest Rohwer, Brandon Reyes, Dimitri D. Deheyn, Robert A. Quinn, Heather Maughan, Mark Little, Clifford A. Kapono, Ana Cobian, Pieter C. Dorrestein, Jennifer E. Smith, Matthieu Leray, Aaron C. Hartmann, Ines Galtier d'Auriac |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
platelet-activating factor Ultraviolet Rays Coral Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound Biosynthesis Immunity Stress Physiological Ultraviolet light Animals Platelet 14. Life underwater Multiple Polyps Platelet Activating Factor phospholipids General Environmental Science General Immunology and Microbiology Platelet-activating factor Ecology fungi technology industry and agriculture General Medicine respiratory system Anthozoa metabolomics Cell biology Aggression Phospholipases A2 030104 developmental biology chemistry coral reef ecology lipids (amino acids peptides and proteins) General Agricultural and Biological Sciences geographic locations Research Article |
| Zdroj: | Proceedings of the Royal Society B: Biological Sciences |
| ISSN: | 1471-2954 |
| Popis: | Corals and humans represent two extremely disparate metazoan lineages and are therefore useful for comparative evolutionary studies. Two lipid-based molecules that are central to human immunity, platelet-activating factor (PAF) and Lyso-PAF were recently identified in scleractinian corals. To identify processes in corals that involve these molecules, PAF and Lyso-PAF biosynthesis was quantified in conditions known to stimulate PAF production in mammals (tissue growth and exposure to elevated levels of ultraviolet light) and in conditions unique to corals (competing with neighbouring colonies over benthic space). Similar to observations in mammals, PAF production was higher in regions of active tissue growth and increased when corals were exposed to elevated levels of ultraviolet light. PAF production also increased when corals were attacked by the stinging cells of a neighbouring colony, though only the attacked coral exhibited an increase in PAF. This reaction was observed in adjacent areas of the colony, indicating that this response is coordinated across multiple polyps including those not directly subject to the stress. PAF and Lyso-PAF are involved in coral stress responses that are both shared with mammals and unique to the ecology of cnidarians. |
| Databáze: | OpenAIRE |
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