Manganese Ferrite nanoparticles encapsulated into vitamin E/Sphingomyelin nanoemulsions as contrast agents for high‐sensitive magnetic resonance imaging
| Autor: | Rafael López-López, Andrés da Silva-Candal, Sandra Díez-Villares, Abi J Vázquez-Ríos, Ramón Iglesias-Rey, Ana B. Dávila-Ibáñez, Pablo Hervella, Maria de la Fuente, Verónica Salgueiriño, Miguel A. Ramos-Docampo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
medicine.diagnostic_test Biomedical Engineering Pharmaceutical Science Nanoparticle Contrast Media 2211.17 Propiedades Magnéticas Magnetic resonance imaging 2210 Química Física Magnetic susceptibility Ferric Compounds Magnetic Resonance Imaging Nanomaterials Sphingomyelins Biomaterials Manganese Compounds In vivo medicine Medical imaging Magnetic nanoparticles Nanoparticles Vitamin E 2202.08 Magnetismo Superparamagnetism Biomedical engineering |
| Zdroj: | Investigo. Repositorio Institucional de la Universidade de Vigo Universidade de Vigo (UVigo) |
| Popis: | Magnetic resonance imaging (MRI) is one of the most powerful non-invasive imaging modalities used in clinics due to its great spatial resolution and excellent soft-tissue contrast, though still less sensitive than other techniques such as the nuclear imaging modalities. This lack of sensitivity can be improved with the use of contrast agents based on nanomaterials. In recent years, researchers have focused on the development of magnetic nanoparticles, given their role as enhancers of the contrast signal based on the magnetic resonance. Manganese ferrite nanoparticles stand out, given their high magnetic susceptibility and magnetic soft nature. Herein, 10 nm MnFe2O4 nanoparticles, functionalized with the natural antioxidant vitamin E (VitE-MFO) are encapsulated into simple, biodegradable and non-toxic nanoemulsions (NEs), by a reproducible one-step method obtaining stable 150 nm-sized magnetic nanoemulsions (VitE-MFO-NEs). After encapsulation, the superparamagnetic properties of VitE-MFO are maintained and MR imaging studies reveal an extremely high transverse relaxivity for VitE-MFO-NEs (652.9 × 10−3 m−1 s−1), twofold higher than VitE-MFO value. Moreover, VitE-MFO-NEs show great in vivo biocompatibility and good signal in in vivo and ex vivo MRI, which indicates their great potential for biomedical imaging enhancing the negative MR contrast and significantly improving the sensitivity of MRI. Instituto de Salud Carlos III | Ref. PI18/00176 Instituto de Salud Carlos III | Ref. AC18/00045 Instituto de Salud Carlos III | Ref. FI19/00206 Axencia Galega de Innovación | Ref. IN853B 2018/03 Ministerio de Ciencia, Innovación y Universidades | Ref. FPU15/06595 Xunta de Galicia | Ref. ED 431C 2016‐034 Xunta de Galicia | Ref. ED 481A 2017/322 |
| Databáze: | OpenAIRE |
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