Long-term Iodine nutrition is associated with longevity in older adults:A 20 years' follow-up of the Randers-Skagen study
| Autor: | Christian Torp-Pedersen, Klaus M. Pedersen, Johannes Riis, Allan Carlé, Mathias Aalkjær Brix Danielsen, Stine Linding Andersen, Martin Bak Jørgensen, Stig Andersen, Gustav Valentin Blichfeldt Sørensen, Inge Bülow Pedersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Denmark media_common.quotation_subject Longevity Iodine nutrition Nutritional Status Medicine (miscellaneous) 030209 endocrinology & metabolism Danish 03 medical and health sciences 0302 clinical medicine longevity Residence Characteristics Humans Medicine 030212 general & internal medicine older adults Aged Iodine intake media_common Aged 80 and over Nutrition and Dietetics business.industry Proportional hazards model thyroid function Drinking Water Hazard ratio tap water Survival Analysis Thyroid Diseases language.human_language Trace Elements Spot urine language Female Thyroid function business Follow-Up Studies Iodine Demography |
| Zdroj: | Riis, J, Pedersen, K M, Danielsen, M B, Sørensen, G V B, Jørgensen, M G, Andersen, S L, Carlé, A, Pedersen, I B, Torp-Pedersen, C & Andersen, S 2021, ' Long-term Iodine nutrition is associated with longevity in older adults : A 20 years' follow-up of the Randers-Skagen study ', British Journal of Nutrition, vol. 125, no. 3, pp. 260-265 . https://doi.org/10.1017/S0007114520001592 Riis, J, Pedersen, K M, Danielsen, M B, Sørensen, G V B, Jørgensen, M G, Andersen, S L, Carlé, A, Pedersen, I B, Torp-Pedersen, C & Andersen, S 2021, ' Long-term Iodine nutrition is associated with longevity in older adults : A 20-year follow-up of the Randers-Skagen study ', British Journal of Nutrition, vol. 125, no. 3, pp. 260-265 . https://doi.org/10.1017/S0007114520001592 |
| DOI: | 10.1017/S0007114520001592 |
| Popis: | Iodine intake affects the occurrence of thyroid disorders. However, the association of iodine intake with longevity remains to be described. This led us to perform a 20 years’ follow-up on participants from the Randers–Skagen (RaSk) study. Residents in Randers born in 1920 (n 210) and Skagen born in 1918–1923 (n 218) were included in a clinical study in 1997–1998. Mean iodine content in drinking water was 2 µg/l in Randers and 139 µg/l in Skagen. We collected baseline data through questionnaires, performed physical examinations and measured iodine concentrations in spot urine samples. Income data were retrieved from Danish registries. We performed follow-up on mortality until 31 December 2017 using Danish registries. Complete follow-up data were available on 428 out of 430 of participants (99·5 %). At baseline, the median urinary iodine concentration was 55 µg/l in Randers and 160 µg/l in Skagen residents. Participants were long-term residents with 72·8 and 92·7 % residing for more than 25 years in Randers and Skagen, respectively. Cox regression showed that living in Skagen compared with Randers was associated with a lower hazard ratio (HR) of death in both age- and sex-adjusted analyses (HR 0·60, 95 % CI 0·41, 0·87, P = 0·006), but also after adjustment for age, sex, number of drugs, Charlson co-morbidity index, smoking, alcohol and income (HR 0·60, 95 % CI 0·41, 0·87, P = 0·008). Residing in iodine-replete Skagen was associated with increased longevity. This indicates that long-term residency in an iodine-replete environment may be associated with increased longevity compared with residency in an iodine-deficient environment. |
| Databáze: | OpenAIRE |
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