Quantitative relationship of Treponema denticola to severity of periodontal disease
| Autor: | C H Goodman, L G Simonson, J J Bial, H E Morton |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pathology
medicine.medical_specialty Immunology Treponema vincentii Population Dental Plaque Biology Dental plaque Microbiology Severe periodontitis stomatognathic system medicine Humans Treponema education Periodontal Diseases Periodontitis Antigens Bacterial education.field_of_study Treponemal Infections Antibodies Monoclonal Treponema denticola medicine.disease biology.organism_classification stomatognathic diseases Infectious Diseases Treponemal Infection Parasitology Research Article |
| Zdroj: | Infection and Immunity. 56:726-728 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.56.4.726-728.1988 |
| Popis: | The Treponema denticola content of plaque was quantitatively estimated for samples taken from periodontitis patients as well as periodontally healthy subjects among two separate human populations. The populations studied included military volunteers and civilians at a university dental clinic. The plaque samples from each population were grouped according to pocket depth measurements at the collection site. A biotin-avidin enzyme-linked immunosorbent assay procedure was developed with a monoclonal antibody specific for a serovariety of T. denticola. T. denticola was present at significantly elevated levels in plaque samples collected from deep-pocket sites of patients with severe periodontitis relative to the healthy controls and a group with moderate disease. The ratio of T. denticola content per milligram of plaque in the deep pocket groups to that of the other two groups was about 2:1 for both populations. This is the first quantitative evidence of a positive relationship between a specific spirochete species and severe periodontitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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