Pharmacokinetics of Carboplatin in a Patient Suffering from Advanced Ovarian Carcinoma with Hemodialysis-Dependent Renal Insufficiency
| Autor: | Etienne Chatelut, Pierre Canal, H. Tonthat, Lionel Rostaing, Georges Houin, Gualano, Jean-Michel Suc, Vissac T, de Forni M |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases medicine.medical_treatment Urology Ovary urologic and male genital diseases Carboplatin chemistry.chemical_compound Papillary adenocarcinoma Pharmacokinetics Renal Dialysis Ovarian carcinoma medicine Humans Aged Ovarian Neoplasms Chemotherapy business.industry medicine.disease female genital diseases and pregnancy complications Surgery medicine.anatomical_structure chemistry Kidney Failure Chronic Chronic renal failure Female Hemodialysis business |
| Zdroj: | Nephron. 66:157-161 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000187794 |
| Popis: | Pharmacokinetics of carboplatin were determined in a patient suffering from advanced ovarian cancer with total hemodialysis-dependent chronic renal failure undergoing 3 consecutive cycles of chemotherapy. Dosage was adjusted to reach active AUC (area under the plasma concentration versus time curve) of ultrafilterable carboplatin. A hemodialysis, performed 24 h after administration results in a decrease of 20% of ultrafilterable carboplatin AUC. The relative dialysis efficacy of ultrafilterable carboplatin was great: 84 +/- 3%. The chemotherapy regimen consisted of carboplatin-cyclophosphamide combination for 6 cycles every 4 weeks. After treatment completion, the patient showed a complete response and remains disease free 16 months after the end of the treatment. Carboplatin-based chemotherapy can be given to patients undergoing chronic hemodialysis without life-threatening toxicity with a dialysis performed 24 h after the administration and with a dose adjustment of carboplatin to reach a AUC of 6 mg/ml.min for untreated patients. In these conditions, response in platinum-sensitive tumors can be obtained. |
| Databáze: | OpenAIRE |
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