Novel radiolabeled antibody conjugates
| Autor: | D M Goldenberg, R M Sharkey |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
biology Antibodies Neoplasm medicine.drug_class Immunotoxins medicine.medical_treatment Cancer Radioimmunotherapy medicine.disease Monoclonal antibody Antigen Neoplasms Immunology Genetics Cancer research biology.protein medicine Animals Humans In patient Antibody Molecular Biology Conjugate Pretargeting |
| Zdroj: | Oncogene. 26:3734-3744 |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | This article reviews the development of radioimmunoconjugates as a new class of cancer therapeutics. Numerous conjugates involving different antigen targets, antibody forms, radionuclides and methods of radiochemistry have been studied in the half-century since radioactive antibodies were first used in model systems to selectively target radiation to tumors. Whereas directly conjugated antibodies, fragments and subfragments have shown promise preclinically, the same approaches have not gained success in patients except in radiosensitive hematological neoplasms, or in settings involving minimal or locoregional disease. The separation of tumor targeting from the delivery of the therapeutic radionuclide in a multistep process called pretargeting has the potential to overcome many of the limitations of conventional, or one-step, radioimmunotherapy, with initial preclinical and clinical data showing increased sensitivity, specificity and higher radiation doses delivered. Our particular focus in pretargeting is the use of bispecific, trimeric (three Fab′s) constructs made by a new antibody engineering method termed ‘dock-and-lock.’ |
| Databáze: | OpenAIRE |
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