The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study
| Autor: | Nurhayat Tugra Ozer, Muhammet Güven, Ender Doğan, Kürşat Gündoğan, Gulsah Gunes Sahin, Murat Sungur, Ismail Hakki Akbudak, Thomas R. Ziegler, Sabahattin Muhtaroğlu, Serap Koşal Şahin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Leptin Male Adipokine critical illness enteral nutrition parenteral nutrition medicine.medical_specialty parenteral nutrition Critical Illness Adipokine Pilot Projects 030204 cardiovascular system & hematology Gastroenterology Article law.invention 03 medical and health sciences 0302 clinical medicine Adipokines Glucagon-Like Peptide 1 law Internal medicine medicine enteral nutrition Humans Resistin Prospective Studies Insulin-Like Growth Factor I Prospective cohort study Aged 0303 health sciences Adiponectin Nutritional Support 030306 microbiology business.industry General Medicine Middle Aged Intensive care unit Ghrelin Parenteral nutrition Female business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Volume: 50, Issue: 4 877-884 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: Adipokines play an important role in the regulation of metabolism. In critical illness, they alter serum levels and are suspected to worsen clinical outcomes. But the effect of the route of nutrition on adipokines is not known. The purpose of this study was to evaluate the association between the route of nutrition and adipokine levels in critically ill patients. Materials and methods: This prospective study was performed in an intensive care unit ICU . Patients admitted to the ICU for least 72 h and receiving either enteral nutrition EN via tube feeding or parenteral nutrition PN were enrolled. Serum was obtained at baseline, 24 h, and 72 h for concentrations of leptin, adiponectin, resistin, glucagon-like peptide 1 GLP-1 , insulin-like growth factors 1 IGF-1 , and ghrelin. Results: A total of 26 patients were included in the study. Thirteen patients received EN and 13 patients received PN. In the PN group, leptin level significantly increased P = 0.037 , adiponectin and ghrelin significantly decreased during follow up P = 0.037, P = 0.008, respectively . There was no significant change between all adipokines in the EN group and resistin, IGF-1 and GLP-1 in the PN group during follow up. Resistin levels were markedly lower in the EN group at both 24 h P = 0.015 and 72 h P = 0.006 while GLP-1 levels were higher in the EN group at baseline, 24 h, and 72 h P = 0.018, P = 0.005, and P = 0.003, respectively . There were no differences in leptin, adiponectin, IGF-1, and ghrelin levels over time. Conclusion: The delivery of EN in critical illness was associated with decreased resistin levels and increased GLP-1 levels. Thus, the route of nutrition may impact the clinical outcome in critical illness due to adipokines. |
| Databáze: | OpenAIRE |
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