Iron overload in Chinese patients with hemoglobin H disease
| Autor: | Hong-Wen Peng, Elizabeth Tse, Shyh-Haw Tsay, Chien-Hui Yung, Mo-Ping Chow, Chung-King Lin, Chao-Hung Ho, Hui-Chi Hsu |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Hemoglobins Abnormal Iron Taiwan Hemosiderosis Gastroenterology Asian People Internal medicine medicine Humans Hemoglobin H Disease Hemochromatosis Aged Hemoglobin H medicine.diagnostic_test biology business.industry Transferrin saturation Hematology Middle Aged medicine.disease Fibrosis Ferritin Hemoglobinopathy Liver Liver biopsy Serum iron biology.protein Thalassemia Female business |
| Zdroj: | American journal of hematology. 34(4) |
| ISSN: | 0361-8609 |
| Popis: | We examined the iron status of 23 adult patients with hemoglobin H (Hb H) disease. None of them had received multiple blood transfusions or prolonged iron therapy. Studies included serum iron and ferritin concentrations, transferrin saturation, a desferrioxamine test, computed tomography (CT) scan of the liver, and liver biopsy. Iron overload was found in 17 patients (73.9%), especially in males and in patients with splenomegaly (92.9% and 100%, respectively). Four patients with excessive alcohol consumption had clinical manifestations of severe iron overload. Idiopathic hemochromatosis associated HLA antigens, i.e., HLA-A3, -B7, or -B14, were not found in any of the 15 patients tested. These findings indicate that iron overload is common in adult patients with Hb H disease; such patients should abstain from alcohol and be considered for treatment with an iron chelating agent before irreversible organ damage occurs. |
| Databáze: | OpenAIRE |
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