Extraction of Synaptic Input Properties in Vivo
| Autor: | Mark C. W. van Rossum, Marta Jelitai, Paolo Puggioni, Ian Duguid |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Patch-Clamp Techniques Cognitive Neuroscience Models Neurological Neural facilitation Biophysics Action Potentials 03 medical and health sciences 0302 clinical medicine Arts and Humanities (miscellaneous) In vivo Interneurons Cerebellum Animals Computer Simulation Event (probability theory) Physics Synaptic scaling Synaptic integration Time constant Electric Stimulation 030104 developmental biology Neural function Synapses Nerve Net Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Puggioni, P, Jelitai, M, Duguid, I & Van Rossum, M 2017, ' Extraction of synaptic input properties in vivo ', Neural Computation . https://doi.org/10.1162/NECO_a_00975 |
| ISSN: | 1530-888X 0899-7667 |
| Popis: | Knowledge of synaptic input is crucial to understand synaptic integration and ultimately neural function. However, in vivo the rates at which synaptic inputsarrive are high, so that it is typically impossible to detect single events. We showhere that it is nevertheless possible to extract the properties of the events, and inparticular to extract the event rate, the synaptic time-constants, and the propertiesof the event size distribution from in vivo voltage-clamp recordings. Applied tocerebellar interneurons our method reveals that the synaptic input rate increasesfrom 600Hz during rest to 1000Hz during locomotion, while the amplitude andshape of the synaptic events are unaffected by this state change. This method thuscomplements existing methods to measure neural function in vivo. |
| Databáze: | OpenAIRE |
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