A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency
| Autor: | Huishan Zhao, Benjiao Gong, Zhi Ma, Mingwei Yu, Yinghua Shan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
premature ovarian insufficiency Pharmaceutical Science epimedium Traditional Chinese medicine Primary Ovarian Insufficiency Bioinformatics Premature ovarian insufficiency 03 medical and health sciences 0302 clinical medicine Molecular level Network pharmacology Drug Discovery Medicine Humans network pharmacology KEGG Medicine Chinese Traditional Original Research Pharmacology Epimedium Drug Design Development and Therapy biology Mechanism (biology) business.industry Computational Biology biology.organism_classification Molecular Docking Simulation 030104 developmental biology GO 030220 oncology & carcinogenesis Molecular mechanism Female business infertility Drugs Chinese Herbal Signal Transduction |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| Popis: | Huishan Zhao,1,* Yinghua Shan,1,* Zhi Ma,1 Mingwei Yu,2 Benjiao Gong31Reproductive Medicine Centre, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 2Department of Orthopaedics and Traumatology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 3Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of ChinaCorrespondence: Huishan ZhaoReproductive Medicine Centre, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of ChinaTel +86 1 861 597 9792Email zhaohuishan1011@163.comBenjiao GongCentral Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of ChinaTel +86 1 835 456 5136Email pumeigong@163.com*These authors contributed equally to this workBackground and purpose: Premature ovarian insufficiency (POI) refers to a hypergonadotropic hypoestrogenism and the condition of pre-onset ovarian function failure. Epimedium is a common traditional Chinese herbal medicine that is widely used to relieve POI in China. To systematically explore the pharmacological mechanism of epimedium on POI therapy, a network pharmacology approach was conducted at the molecular level.Methods: In this study, we adopt the network pharmacology method, which mainly includes active ingredients prescreening, target prediction, gene enrichment analysis and network analysis.Results: The network analysis revealed that 6 targets (ESR1, AR, ESR2, KDR, CYP19A1 and ESRRG) might be the therapeutic targets of epimedium on POI. In addition, gene-enrichment analysis suggested that epimedium appeared to play a role in POI by modulating 6 molecular functions, 5 cellular components, 15 biological processes and striking 52 potential targets involved in 13 signaling pathways.Conclusion: This study predicted the pharmacological and molecular mechanism of epimedium against POI from a holistic perspective, as well as provided a powerful tool for exploring pharmacological mechanisms and rational clinical application of traditional Chinese medicine.Keywords: network pharmacology, premature ovarian insufficiency, epimedium, infertility, GO, KEGG |
| Databáze: | OpenAIRE |
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