Prognostic Impact of LGR5, Prox1, and Notch1 Biomarkers in Stage II to III Colon Cancer
| Autor: | Ahmed El-Azony, Eman A. Elsebai, Aziza E. Abdelrahman, Hanaa M. Ibrahim |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Histology Colorectal cancer Stage ii Pathology and Forensic Medicine Metastasis Receptors G-Protein-Coupled Testicular Neoplasms Tumor stage medicine Biomarkers Tumor Humans Receptor Notch1 Homeodomain Proteins business.industry Tumor Suppressor Proteins Wnt signaling pathway LGR5 medicine.disease Prognosis Medical Laboratory Technology Lymphatic Metastasis Colonic Neoplasms Cancer research Neoplastic Stem Cells Immunohistochemistry Stem cell Neoplasm Recurrence Local business Biomarkers Transcription Factors |
| Zdroj: | Applied immunohistochemistrymolecular morphology : AIMM. 30(2) |
| ISSN: | 1533-4058 |
| Popis: | The potentiation and activation of Wnt signaling pathways are now assumed to mediate the self-renewal and proliferation of colon cancer stem cells that are responsible for therapeutic resistance, tumor relapse, and metastasis. We aimed to evaluate LGR5, Prox1, and Notch1 immunohistochemical expression in stage II to III colon cancer. Their predictive role of tumor relapse, overall survival, and disease-free survival was statistically analyzed. Our results revealed that high LGR5 expression was identified in 56.7% of the patients, LGR5 expression was significantly associated with left-sided tumors (P |
| Databáze: | OpenAIRE |
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