Evaluation of microwave ablation for local treatment of dogs with distal radial osteosarcoma: A pilot study
| Autor: | Joelle M. Fenger, Sarah A. Salyer, Vincent A Wavreille, Ryan N. Jennings, Laura E. Selmic |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment Bone Neoplasms Pilot Projects 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine medicine Animals Clinical significance Dog Diseases Microwaves Osteosarcoma Radiofrequency Ablation General Veterinary business.industry Microwave ablation Soft tissue 04 agricultural and veterinary sciences medicine.disease Ablation Radius Treatment Outcome Primary bone Amputation Fluoroscopy 030220 oncology & carcinogenesis Female Histopathology business Nuclear medicine |
| Zdroj: | Veterinary Surgery. 49:1396-1405 |
| ISSN: | 1532-950X 0161-3499 |
| DOI: | 10.1111/vsu.13491 |
| Popis: | OBJECTIVE To evaluate the feasibility and safety of microwave ablation (MWA) as a modality to induce tumor necrosis within distal radial osteosarcoma (OSA). STUDY DESIGN Pilot study. ANIMALS Six client-owned dogs with distal radius OSA confirmed by cytological examination. METHODS Dogs underwent computed tomography for surgical planning before general anesthesia for fluoroscopy-guided ablation. Computed tomography was repeated 48 hours after MWA, before amputation. The ablated tumor was evaluated with histopathology. RESULTS Six dogs underwent MWA of distal radius OSA. A lower power setting (30 W) was selected for the first two dogs to avoid collateral soft tissue damage. The power was increased to 75 W for the last four dogs. The temperature was maintained between 45°C and 55°C (113 °F-131 °F) at the bone/soft tissue interface. Tumor necrosis varied between 30% and 90% (median, 55%) according to histopathology. No intraoperative or periprocedural complications were observed. CONCLUSION Microwave ablation induced variable tumor necrosis and did not induce immediate postablation complications in these six dogs with distal radius OSA. CLINICAL SIGNIFICANCE These results justify further evaluation of MWA as a potential modality to treat primary bone lesions in dogs. |
| Databáze: | OpenAIRE |
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