The blood/cerebrospinal fluid partitioning of pyrazinamide: a study during the course of treatment of tuberculous meningitis
| Autor: | K Supmonchai, S Kaojarern, C Mokkhavesa, Prida Phuapradit |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Tuberculosis Adolescent Antitubercular Agents Gastroenterology Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Pharmacokinetics Internal medicine medicine Humans CSF albumin Aged biology business.industry Middle Aged Pyrazinamide medicine.disease biology.organism_classification Psychiatry and Mental health Blood-Brain Barrier Tuberculosis Meningeal Drug Therapy Combination Female Surgery Neurology (clinical) business Meningitis Follow-Up Studies Research Article medicine.drug |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 53:81-82 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.53.1.81 |
| Popis: | Concentrations of pyrazinamide were measured in serum and cerebrospinal fluid (CSF) of 17 adult patients with tuberculous meningitis up to six months after starting treatment. Pyrazinamide penetrated excellently into the CSF and mean concentrations at various intervals up to six months of treatment were consistently above that required for inhibition of the growth of Mycobacterium tuberculosis. The blood/CSF partitioning of pyrazinamide does not change as the patients recover from the meningitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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