Acute citrulline oral supplementation induces greater post-exercise hypotension response in hypertensive than normotensive individuals
| Autor: | João Vagner Cavalari, Renata Cristina Góes, Kamila Grandolfi, Juliano Casonatto, Marcos Doederlein Polito |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Ambulatory blood pressure
Medicine (miscellaneous) lcsh:TX341-641 030204 cardiovascular system & hematology Placebo 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Citrulline Medicine Treadmill Exercise Nutrition and Dietetics business.industry 030229 sport sciences Dietary supplements Blood pressure chemistry Anesthesia Ambulatory Hypertension Post-Exercise Hypotension business Corn starch lcsh:Nutrition. Foods and food supply |
| Zdroj: | Revista de Nutrição v.31 n.6 2018 Revista de Nutrição Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP Revista de Nutrição, Vol 31, Iss 6, Pp 509-521 |
| Popis: | Objective To investigate whether acute citrulline supplementation might influence post-exercise hypotension in normotensive and hypertensive individuals. Methods Following a randomized double-blind design, twenty normotensive (28±7 years, 74±17kg, 1.7±0.09m) and 20 hypertensive individuals (55±12 years, 76±15kg, 1.59±0.09m) were randomly assigned to one of the four experimental groups (Normotensive-Placebo; Normotensive-Citrulline; Hypertensive-Placebo; Hypertensive-Citrulline). The placebo groups ingested 6g of corn starch and the citrulline groups ingested 6g of citrulline dissolved in water. The participants performed 40 minutes of walking/running on a treadmill at 60-70% heart rate reserve. Blood pressure was measured immediately after a 60-min exercise session using an oscillometric device and 24-h ambulatory monitoring. Results The post-exercise hypotension was more pronounced in hypertensives and the Hypertensive-Citrulline group showed a consistent systolic blood pressure reduction during the laboratorial phase, which can be seen by looking at the mean of 60 minutes (-15.01mmHg vs -3.14mmHg [P=0.005]; -4.16mmHg [P=0.009]; -6.30mmHg [P=0.033] in comparison with the Normotensive-Placebo, Normotensive-Citrulline, and Hypertensive-Placebo groups, respectively). During ambulatory blood pressure monitoring, the Hypertensive-Citrulline group showed a significant reduction in systolic blood pressure (-21.05mmHg) in the awake period compared with the Normotensive-Citrulline group (-3.17mmHg [P=0.010]). Conclusion Acute citrulline oral supplementation can induce greater post-exercise hypotension response in hypertensive than normotensive individuals. |
| Databáze: | OpenAIRE |
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