Bone-like Polymeric Composites with a Combination of Bioactive Glass and Hydroxyapatite: Simultaneous Enhancement of Mechanical Performance and Bioactivity
| Autor: | Baisong Zhao, Wei Liu, Hua-Mo Yin, Jia-Zhuang Xu, Yue Ren, Yan-Fei Huang, Zhong-Ming Li, Rizwan M. Gul |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Toughness
Bone substitute Simulated body fluid Biomedical Engineering 02 engineering and technology Molding (process) Polyethylene 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Mineralization (biology) 0104 chemical sciences law.invention Biomaterials chemistry.chemical_compound chemistry law Bioactive glass Alkaline phosphatase Composite material 0210 nano-technology |
| Zdroj: | ACS biomaterials scienceengineering. 4(12) |
| ISSN: | 2373-9878 |
| Popis: | An ideal bone substitute requires not only high bioactivity but also sufficient mechanical performance, which is however inaccessible due to the lack of rational structure and composition design. Here, bioactive glass (BG)/hydroxyapatite (HA)/polyethylene (PE) composites with bone-like structure were prepared via a structuring injection molding. The strong and reciprocating shear field offered by the modified injection molding induced plenty of interlocked shish kebabs, mimicking the aligned collagen fibers in the natural bone. Such a bone-like structure enhanced the strength and toughness of the BG/HA/PE composites simultaneously, compensating the mechanical loss caused by the presence of BG. In vitro cell culture assays demonstrated that the combination of BG and HA significantly promoted cell attachment, proliferation, and alkaline phosphatase activity compared to the use of HA alone. It was attributed to upregulated expression of β-catenin stimulated by BG. The mineralization in simulated body fluid r... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|