Mitoxantrone, Etoposide, Carboplatinum and Ara-C Combination Therapy (Meca) in Refractory and Relapsed Acute Leukemia
| Autor: | David Gallardo, A Grañena, González, J. J. Berlanga, Josep Sarrá, I Ancín, Juan D. Muñoz, D Marìn, Christelle Ferra, J Peris |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Combination therapy Pharmacology Disease-Free Survival Carboplatin Myelogenous chemistry.chemical_compound Actuarial Analysis Recurrence Risk Factors Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Etoposide Salvage Therapy Acute leukemia Mitoxantrone Leukemia business.industry Cytarabine Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Treatment Outcome chemistry Acute Disease Female business medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 39:583-590 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | The present study was undertaken to assess the feasibility, toxicity and antileukemic activity of sequential chemotherapy including mitoxantrone, etoposide, carboplatin and intermediate-dose cytarabine in adult patients with refractory and relapsed acute myelogenous (AML) or lymphoid (ALL) leukemia. Fifty-one patients with poor-risk AML and ALL received 64 courses of MECA therapy. The overall response in the entire group was 51% (43% complete remission). The stage of the disease (relapsed or primarily refractory) and the age of the patients did not strongly affect the response rate. MECA therapy was more effective in ALL than in AML, and in those patients who presented at salvage treatment with a bone marrow infiltration lower than 25% blasts. Hematological and extra-hematological toxicities were tolerable and there were 6 deaths related to the treatment (11%). The incidence of documented infectious episodes was 71%. MECA therapy is a safe treatment and has a high antileukemic activity in relapsed and primarily refractory AML or ALL. |
| Databáze: | OpenAIRE |
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