Deltex1 Redirects Lymphoid Progenitors to the B Cell Lineage by Antagonizing Notch1
| Autor: | Vytas Patriub, Lanwei Xu, Jon C. Aster, Yiping He, David J Izon, Carlos G. Rodriguez, Warren S. Pear, Fredrick G. Karnell, David Allman, Sonia Bakkour, Andrew P. Weng |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Transcriptional Activation
Recombinant Fusion Proteins T-Lymphocytes T cell Cellular differentiation Immunology Gene Expression Bone Marrow Cells Receptors Cell Surface Thymus Gland Biology Mice Organ Culture Techniques Coactivator Basic Helix-Loop-Helix Transcription Factors Tumor Cells Cultured medicine Animals Humans Immunology and Allergy Cell Lineage Lymphocytes Receptor Notch1 Progenitor cell Transcription factor B cell Cell Line Transformed B-Lymphocytes Membrane Proteins Proteins Cell Differentiation 3T3 Cells Hematopoietic Stem Cells Fetal Thymic Organ Culture Cell biology DNA-Binding Proteins medicine.anatomical_structure Infectious Diseases Liver Protein Biosynthesis embryonic structures cardiovascular system sense organs biological phenomena cell phenomena and immunity Signal transduction Carrier Proteins Signal Transduction Transcription Factors |
| Zdroj: | Immunity. 16(2):231-243 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/s1074-7613(02)00271-6 |
| Popis: | Notch1 signaling drives T cell development at the expense of B cell development from a common precursor, an effect that is dependent on a C-terminal Notch1 transcriptional activation domain. The function of Deltex1, initially identified as a positive modulator of Notch function in a genetic screen in Drosophila, is poorly understood. We now demonstrate that, in contrast to Notch1, enforced expression of Deltex1 in hematopoietic progenitors results in B cell development at the expense of T cell development in fetal thymic organ culture and in vivo. Consistent with these effects, Deltex1 antagonizes Notch1 signaling in transcriptional reporter assays by inhibiting coactivator recruitment. These data suggest that a balance of inductive Notch1 signals and inhibitory signals mediated through Deltex1 and other modulators regulate T-B lineage commitment. |
| Databáze: | OpenAIRE |
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