Biological determinants of health disparities in multiple myeloma
| Autor: | Cheryl J. Smith, Ola Landgren, Stefan Ambs |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty African descent Review Article Disease Monoclonal Gammopathy of Undetermined Significance lcsh:RC254-282 03 medical and health sciences Race (biology) 0302 clinical medicine Population Groups Epidemiology Prevalence Humans Medicine Social determinants of health Family history 10. No inequality Multiple myeloma business.industry Cancer Health Status Disparities Hematology Prognosis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 3. Good health 030104 developmental biology Oncology Population Surveillance 030220 oncology & carcinogenesis Female Disease Susceptibility Multiple Myeloma business Demography |
| Zdroj: | Blood Cancer Journal, Vol 8, Iss 9, Pp 1-7 (2018) Blood Cancer Journal |
| ISSN: | 2044-5385 |
| Popis: | Multiple myeloma is a rare plasma cell cancer, and incidence rates among patients of African descent are about twice those among patients of European descent. Rates of multiple myeloma vary among different populations, but the reasons for the racial disparities in multiple myeloma are largely unknown. Epidemiology has identified risk factors for multiple myeloma including race, advanced age, gender, family history, and exposure to different genetic toxins including radiation. Race and ancestry play a large role in predicting the risk for multiple myeloma, yet there exists a paucity of literature that explores the molecular contribution of race and ancestry to disease. In this review, we describe the relevant literature that describes the observed racial differences according to distinct tumor immunobiological and ancestral differences in populations. |
| Databáze: | OpenAIRE |
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