Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology
| Autor: | Carole Van Haverbeke, Jo Van Dorpe, Liesbeth Ferdinande, Uta Flucke, David Creytens, Evelyne Lecoutere |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Dedifferentiated liposarcoma Heterologous Histopathological examination Liposarcoma Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] Pathology and Forensic Medicine osteosarcomatous 03 medical and health sciences 0302 clinical medicine MDM2 Journal Article medicine Humans Retroperitoneal Neoplasms neoplasms Aged Retroperitoneal mass business.industry Mesenchymal stem cell Aneurysmal bone cyst medicine.disease body regions 030104 developmental biology dedifferentiated liposarcoma liposarcoma aneurysmal bone cyst 030220 oncology & carcinogenesis Immunohistochemistry Surgery Female Anatomy Neoplasm Recurrence Local business |
| Zdroj: | International Journal of Surgical Pathology, 25, 374-378 International Journal of Surgical Pathology, 25, 4, pp. 374-378 International journal of surgical pathology, 25(4), 374. SAGE Publications Inc. |
| ISSN: | 1066-8969 |
| Popis: | Item does not contain fulltext A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma. |
| Databáze: | OpenAIRE |
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