Effect of estradiol and Remifemin on the dorsal lingual epithelium of ovariectomized rats
| Autor: | Wenjuan Wang, Xiaofeng Luo, Shuya Liu, Ke Wang, Kaiyu Niu, Jing Jia, Yunmeng Da, Lihua Qin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Cimicifuga medicine.drug_class Ovariectomy Black cohosh Biochemistry Epithelium Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Endocrinology Tongue Epidermal growth factor Internal medicine Genetics medicine Animals Humans Molecular Biology biology Estradiol business.industry Plant Extracts Estrogens Cell Biology medicine.disease Proliferating cell nuclear antigen Rats Menopause 030104 developmental biology Apoptosis Estrogen Ovariectomized rat biology.protein Immunohistochemistry Female business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Experimental gerontology. 143 |
| ISSN: | 1873-6815 |
| Popis: | Background In this study, the ovariectomized rat model was used to explore the impact of menopause on rats' dorsal lingual epithelium; at the same time, the curative effects of Remifemin and estradiol were also observed. Methods 28 adult female Sprague-Dawley rats were divided into four groups randomly, including sham-operated group (SHAM), an ovariectomized group (OVX), an ovariectomized treated with estradiol (OVX + E), an ovariectomized treated with Remifemin (OVX + iCR). Variation and possible mechanisms were studied via morphology, immunohistochemistry and electron microscope. Results The results showed that the dorsal lingual epithelium became thinner significantly in the apex part in OVX group, as well as the levels of proliferating cell nuclear antigen (PCNA) and the epidermal growth factor (EGF) were lower than that in other three groups. However, they could reverse close to normal after estradiol and Remifemin treatment respectively. Conclusion The thinning in the apex of dorsal lingual epithelium might be due to the reduced proliferation in the germinal layer led by the abating of estrogen level, instead of apoptosis. This might play an important role in the pathogenesis of the menopause female tongue burning sensation. Remifemin had certain curative effect on the dorsal lingual mucosa, but a little more inferior than estrogen. |
| Databáze: | OpenAIRE |
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