The effects of a mixed fish diet on platelet function, fatty acids and serum lipids
| Autor: | N. Chetty, B.A. Bradlow, J. van der Westhuyzen, D Mendelsohn, J E Gibson |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.medical_specialty Epinephrine Platelet Aggregation Blood lipids Arachidonic Acids Biology Thromboxane Production chemistry.chemical_compound Internal medicine medicine Animals Humans Platelet Triglycerides Arachidonic Acid Triglyceride Cholesterol Fatty Acids Fishes Hematology Eicosapentaenoic acid Diet Adenosine Diphosphate Endocrinology chemistry Eicosapentaenoic Acid Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Arachidonic acid Female Collagen medicine.drug |
| Zdroj: | Thrombosis research. 29(6) |
| ISSN: | 0049-3848 |
| Popis: | Eight healthy subjects were fed a diet containing 1–4 g eicosapentaenoic acid (EPA) daily for 8–21 days. The EPA was derived from 300–400 g per day of sardines, pilchards, herring and/or kabeljou. Sources of arachidonic acid (AA) in the diet were reduced. At the end of the experimental period there was an increase in the ratio of EPA to AA in the platelets and a decrease in platelet aggregation to ADP, epinephrine and collagen. Aggregation to AA was not reduced. Thromboxane production in response to all four agonists was reduced. Serum total and HDL cholesterol levels fell significantly but platelet counts, LDL cholesterol and triglyceride values did not change. We conclude that even a relatively modest intake of EPA derived from a mixed fish diet together with a reduction in AA intake can alter in vitro platelet function and serum lipids significantly. A long term controlled trial of a palatable mixed fish diet to assess possible antithrombotic and antiatherogenic effects is justifiable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|