Tumor volume and metabolism of prostate cancer determined by proton magnetic resonance spectroscopic imaging at 3T without endorectal coil reveal potential clinical implications in the context of radiation oncology
| Autor: | Mathilde Funes de la Vega, Céline Mirjolet, Philippe Maingon, Alexandre Cochet, Paul Walker, François Brunotte, Douraied Ben Salem, Sébastien Parfait, Franck Bonnetain, Mélanie Liegard, Gilles Créhange, Luc Cormier |
|---|---|
| Přispěvatelé: | Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Department of Anatomo-Pathology, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service d'Urologie [CHU de Dijon], Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Groupe d'Etude de la Thrombose de Bretagne Occidentale ( GETBO ), Université de Brest ( UBO ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Service d'urologie, Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Cancer Research MESH : Polyamines MESH: Tumor Burden Magnetic Resonance Spectroscopy MESH : Retrospective Studies [SDV]Life Sciences [q-bio] MESH : Aged MESH: Risk Assessment MESH : Choline Choline 030218 nuclear medicine & medical imaging chemistry.chemical_compound Prostate cancer 0302 clinical medicine Prostate MESH : Tumor Markers Biological Polyamines MESH : Neoplasm Staging Stage (cooking) MESH : Prostate-Specific Antigen MESH : Risk Assessment MESH: Aged Radiation MESH : Prognosis MESH: Middle Aged medicine.diagnostic_test [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging MESH : Tumor Burden MESH: Creatine MESH: Choline Magnetic resonance spectroscopic imaging MESH: Neoplasm Staging Middle Aged Prognosis MESH : Creatine Tumor Burden 3. Good health MESH: Prostate-Specific Antigen medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis MESH : Prostatic Neoplasms MESH: Citric Acid MESH : Male Context (language use) MESH : Citric Acid Creatine Risk Assessment Citric Acid MESH: Prognosis 03 medical and health sciences Biomarkers Tumor medicine [INFO.INFO-IM]Computer Science [cs]/Medical Imaging Humans Radiology Nuclear Medicine and imaging MESH : Middle Aged MESH: Polyamines Aged Neoplasm Staging Retrospective Studies MESH: Humans [ SDV ] Life Sciences [q-bio] business.industry MESH: Magnetic Resonance Spectroscopy MESH : Humans Prostatic Neoplasms Magnetic resonance imaging MESH: Retrospective Studies Prostate-Specific Antigen medicine.disease MESH: Male chemistry MESH: Prostatic Neoplasms MESH: Tumor Markers Biological MESH : Magnetic Resonance Spectroscopy business Nuclear medicine |
| Zdroj: | International Journal of Radiation Oncology-Biology-Physics International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2011, 80 (4), pp.1087-1094. ⟨10.1016/j.ijrobp.2010.03.007⟩ International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2011, 80 (4), pp.1087-94. ⟨10.1016/j.ijrobp.2010.03.007⟩ International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2011, 80 (4), pp.1087-94. 〈10.1016/j.ijrobp.2010.03.007〉 International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2011, 80 (4), pp.1087-1094. 〈10.1016/j.ijrobp.2010.03.007〉 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2010.03.007⟩ |
| Popis: | International audience; Abstract PURPOSE: To determine whether a relationship exists between the tumor volume (TV) or relative choline content determined using magnetic resonance spectroscopy imaging (MRSI) at 3T and the clinical prognostic parameters for patients with localized prostate cancer (PCa). METHODS AND MATERIALS: A total of 72 men (mean age, 67.8 ± 6.2 years) were stratified as having low-risk (n = 26), intermediate-risk (n = 24), or high-risk (n = 22) PCa. MRSI was performed at 3T using a phased-array coil. Spectra are expressed as the total choline/citrate, total choline plus creatine/citrate, and total choline plus polyamines plus creatine/citrate ratios. The mean ratio of the most pathologic voxels and the MRSI-based TV were also determined. RESULTS: The mean values of the total choline/citrate, total choline plus creatine/citrate, and total choline plus polyamine plus creatine/citrate ratios were greater for Stage T2b or greater tumors vs. Stage T2a or less tumors: 7.53 ± 13.60 vs. 2.31 ± 5.65 (p = .018), 8.98 ± 14.58 vs. 2.56 ± 5.70 (p = .016), and 10.32 ± 15.47 vs. 3.55 ± 6.16 (p = .014), respectively. The mean MRSI-based TV for Stage T2b or greater and Stage T2a or less tumors was significantly different (2.23 ± 2.62 cm(3) vs. 1.26 ± 2.06 cm(3), respectively; p = .030). This TV correlated with increased prostate-specific antigen levels (odds ratio, 1.293; p = .012). Patients with high-risk PCa had a larger TV than did the patients with intermediate-risk PCa. A similar result was found for the intermediate-risk group compared with the low-risk group (odds ratio, 1.225; p = .041). CONCLUSION: Biomarkers expressing the relative choline content and TV were significant parameters for the localization of PCa and could be helpful for determining the prognosis more accurately. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|