Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice
| Autor: | Mohammad Shokrzadeh, Amirhossein Ahmadi, Aroona Chabra, Farshad Naghshvar, Mehdi Jafarinejhad |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Article Subject Cyclophosphamide medicine.medical_treatment lcsh:Medicine Pharmacology Protective Agents medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology Melatonin Lipid peroxidation Mice chemistry.chemical_compound Internal medicine medicine Animals Chemotherapy General Immunology and Microbiology business.industry lcsh:R General Medicine Oxidative Stress Endocrinology medicine.anatomical_structure Liver chemistry Hepatocyte Toxicity Lipid Peroxidation Chemical and Drug Induced Liver Injury business hormones hormone substitutes and hormone antagonists Oxidative stress Research Article Blood sampling medicine.drug |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2014/470425 |
| Popis: | The current study aimed to evaluate the protective effects of melatonin, a pineal secretory product, against hepatotoxicity induced by cyclophosphamide (CP) in mice. Mice were pretreated with melatonin intraperitoneally for 7 consecutive days before the administration of a single intraperitoneal dose of 200 mg/kg CP. 24 hr after CP administration, the mice were anesthetized, blood was then removed, and serum toxicity enzymes activities were evaluated. After the blood sampling, all animals were killed, livers were then removed, and histological studies were conducted. Serum toxicity marker enzymes were significantly increased after CP treatment but restored in melatonin pretreated groups. In addition, administration of CP induced necrotic hepatocyte with small crushed nuclei, portal space with severe inflammation, and hepatocytes surrounded by lymphocytic infiltration in hepatic tissues. However, melatonin effectively protected against CP-induced histopathological abnormalities in the liver tissues. Our results reveal that melatonin produces a potent hepatoprotective mechanism against CP. Therefore, melatonin could be a potent candidate to use concomitantly as a supplement agent against hepatotoxicity of CP for the patients undergoing chemotherapy. |
| Databáze: | OpenAIRE |
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