Agouti-related protein prevents self-starvation
| Autor: | Antonius Scheurink, Rah Adan, Martien J H Kas, van Gertjan Dijk |
|---|---|
| Přispěvatelé: | Van Dijk lab, Scheurink lab |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Pro-Opiomelanocortin
MELANOCORTIN-4 RECEPTOR Gene Expression Pituitary-Adrenal System anorexia nervosa Agouti-Related Protein Receptor biology Receptors Melanocortin Leptin digestive oral and skin physiology melanocortin receptor Melanocortin 4 receptor Psychiatry and Mental health Hypothalamus OBESITY Intercellular Signaling Peptides and Proteins Female medicine.symptom Melanocortin PITUITARY-ADRENAL-AXIS hormones hormone substitutes and hormone antagonists Hypothalamo-Hypophyseal System medicine.medical_specialty ANOREXIA-NERVOSA fasting Anorexia Motor Activity RATS PROOPIOMELANOCORTIN Cellular and Molecular Neuroscience LEPTIN Proopiomelanocortin Melanocortin receptor Internal medicine Animals Outbred Strains medicine Animals Rats Wistar Molecular Biology Caloric Restriction Proteins Feeding Behavior hyperactivity MICE Endocrinology Receptors Corticotropin Ventromedial Hypothalamic Nucleus biology.protein body temperature SYSTEM RESPONSES |
| Zdroj: | Molecular Psychiatry, 8(2), 235-240. Nature Publishing Group |
| ISSN: | 1359-4184 |
| DOI: | 10.1038/sj.mp.4001206 |
| Popis: | Food restriction leads to a paradoxical increase in physical activity and further suppression of food intake, such as observed in anorexia nervosa.(1,2) To understand this pathophysiological process, we induced physical hyperactivity and self-starvation in rats by restricting food in the presence of running wheels. Normally, decreased melanocortin receptor activity will prevent starvation.(3,4) However, we found that self-starvation increased melanocortin receptors in the ventral medial hypothalamus, a brain region involved in eating behavior.(5) Suppression of melanocortin receptor activity, via central infusion of Agouti-related protein (AgRP), increased survival rate in these rats by counteracting physical hyperactivity, food intake suppression as well as deregulated body temperature. We conclude that self-starvation may result from insufficient suppression of central melanocortin receptor activity. |
| Databáze: | OpenAIRE |
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