Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects
| Autor: | Hyunsoon Cho, Joyce B. Harp, Kimberly A Brownley, Karen A. Graham |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Glucose Leptin Male medicine.medical_specialty Psychosis Diabetes risk Adolescent Disease Article Statistics Nonparametric Body Mass Index Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Insulin Risk factor Young adult Psychiatry Triglycerides Biological Psychiatry Retrospective Studies First episode business.industry Cholesterol HDL Retrospective cohort study Cholesterol LDL medicine.disease Psychiatry and Mental health Psychotic Disorders Cardiovascular Diseases Female business Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Schizophrenia Research. 101:287-294 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2007.12.476 |
| Popis: | To examine prospective changes in cardiovascular disease (CVD) and type-2 diabetes risk factors in young adult first episode psychotic (FEP) patients treated with second generation antipsychotic medications.At baseline, fasting serum and anthropometric measures were obtained from 45 FEP patients and 41 healthy adults (controls) of similar age, ethnicity and sex; sixteen of the FEP patients remained on the same antipsychotic medication and were available for a second blood draw at 24 weeks of treatment. Serum was assayed for glucose, insulin, triglycerides, total cholesterol and high and low density lipoproteins (HDL, LDL), adiponectin, leptin, interleukin 6, E-selectin and VCAM-1. Wilcoxon nonparametric tests were used to compare risk markers between the FEP and control group at baseline and to evaluate pre-post treatment changes within the FEP group.At baseline, the distributions of risk marker values were similar between the two groups and the percentages of FEP patients and healthy controls who were overweight/obese, dyslipidemic, hyperglycemic, and hyperinsulinemic did not differ. At 24 weeks, compared to baseline, FEP patients showed significant increases in BMI (p=0.0002), glucose (p=0.0449), insulin (p=0.0161), cholesterol (p=0.0129), leptin (p=0.0215), and E-selectin (p=0.0195), and a decrease in adiponectin (p=0.0371).Among patients with first episode psychosis, 6-month treatment with second generation antipsychotics is associated with the exacerbation of pre-existing and emergence of new CVD and diabetes risk factors. |
| Databáze: | OpenAIRE |
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