Parkin uses the UPS to ship off dysfunctional mitochondria
| Autor: | David C. Chan, Nickie C. Chan |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Proteasome Endopeptidase Complex
biology Ubiquitin Ubiquitin-Protein Ligases Autophagy Cell Biology Mitochondrion Models Biological Autophagic Punctum Parkin Mitochondria nervous system diseases Ubiquitin ligase Cell biology Proteasome Mitophagy biology.protein Animals Bacterial outer membrane Molecular Biology |
| Zdroj: | Autophagy. 7:771-772 |
| ISSN: | 1554-8635 1554-8627 |
| DOI: | 10.4161/auto.7.7.15453 |
| Popis: | Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous studies have established its role in mitophagy, a pathway whereby dysfunctional mitochondria are targeted for autophagic degradation. We recently reported that a major function of Parkin in dysfunctional mitochondria is to activate the ubiquitin-proteasome system (UPS) for proteolysis of multiple outer membrane proteins, and that such activation of the UPS is a critical step in Parkin-mediated mitophagy. Here, we discuss the possible roles of the UPS in mitophagy and the pathogenesis of PD. |
| Databáze: | OpenAIRE |
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