Electrical characterization of DNA supported on nitrocellulose membranes
| Autor: | Mahmoud Al Ahmad, Reham M. Milhem, Tahir A. Rizvi, Neena G. Panicker, Farah Mustafa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Membranes
Multidisciplinary Materials science Oligonucleotide 010401 analytical chemistry Oligonucleotides Analytical chemistry Collodion DNA 02 engineering and technology DNA Solutions Dielectric 021001 nanoscience & nanotechnology 01 natural sciences Capacitance Article 0104 chemical sciences chemistry.chemical_compound Membrane Electricity chemistry 0210 nano-technology Polarization (electrochemistry) Nitrocellulose |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep29089 |
| Popis: | Integrated DNA-based nanoscale electronic devices will enable the continued realization of Moore’s Law at the level of functional devices and systems. In this work, the electrical characterization of single and complementary base paired DNA has been directly measured and investigated via the use of nitrocellulose membranes. A radio frequency DAKS-3.5 was used to measure the reflection coefficients of different DNA solutions dotted onto nitrocellulose membranes. Each DNA solution was exposed to a radio frequency signal with a power of 10 dBm and with a sweep from 200 MHz up to 13.6 GHz. The conducted measurements show some distinctions between the homomeric and complementary bases due to their different electrical polarization. As revealed from the measurements conducted, with the addition of DNA oligonucleotides, the measured capacitance increased when compared with buffer medium alone. The DNA molecules could be modeled as dielectric material that can hold electrical charges. Furthermore, the complementary paired DNA molecule-based inks solutions had a higher capacitance value compared with single DNA molecules (A, C, G and T) solutions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|