Secretory component and lactoferrin in pure pancreatic juice in chronic pancreatitis
| Autor: | Murase T, Tetsuo Hayakawa, Koji Ochi, Takaharu Kondo, Tokimune Shibata, Hideo Harada, Juntaro Tanaka |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
musculoskeletal diseases medicine.medical_specialty Low protein Pancreatic disease Physiology Secretory component Pancreatic Juice Internal medicine medicine Humans Amylase skin and connective tissue diseases Aged biology Lactoferrin Chemistry Gastroenterology Calcinosis Proteins Middle Aged medicine.disease Secretory Component Endocrinology Secretory protein Pancreatitis Amylases Chronic Disease Pancreatic juice biology.protein |
| Zdroj: | Digestive Diseases and Sciences. 38:7-11 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf01296766 |
| Popis: | To evaluate pathophysiological roles of proteins in pancreatic secretion, immunoreactive lactoferrin (LF) and secretory component (SC) were measured in the first fraction of the pure pancreatic juice obtained endoscopically from 17 control, 21 suspected (SCP), 14 noncalcified (NCP), and 14 calcified chronic pancreatitis (CCP) subjects. The protein and amylase tended to decrease both in concentration and output from control to CCP. LF concentration was elevated in CCP (18.0 +/- 4.9 micrograms/ml) when compared with controls (2.3 +/- 0.2 micrograms/ml), and LF output in NCP (12.3 +/- 3.8 micrograms/min) was increased from controls (3.8 +/- 0.6 micrograms/min). The combination of high LF concentration with low protein output was observed in 10/14 in CCP but 0/14 in NCP and can be a biochemical discriminator of CCP from NCP. SC concentrations were also elevated in NCP (8.5 +/- 2.0 micrograms/ml) and CCP (5.6 +/- 1.6 micrograms/ml) from controls (1.2 +/- 0.2 micrograms/ml). SC outputs in SCP (9.8 +/- 3.1 micrograms/min) and NCP (21.1 +/- 4.8 micrograms/min) were increased from controls (1.7 +/- 0.3 micrograms/min), but there was no further increase in CCP. Hypersecretion of LF and SC in chronic pancreatitis is different, especially in CCP, although the mechanisms for hypersecretion are unknown. |
| Databáze: | OpenAIRE |
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