Hemodynamic response to low-flow acute supplemental oxygen in idiopathic pulmonary fibrosis and elderly healthy subjects
| Autor: | Ivette Buendía-Roldán, S. Reulecke, Sonia Charleston-Villalobos, Laura Mercedes Santiago-Fuentes, Ramón González-Camarena, Geovanni Benítez-Valdez, T. Aljama-Corrales, M.J. Gaitán-González, M. Mejia-Avila |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac output medicine.medical_specialty Haemodynamic response Hemodynamics 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Internal medicine Heart rate medicine Humans Cardiac Output Aged Oxygen saturation (medicine) Aged 80 and over business.industry Stroke volume Middle Aged medicine.disease Healthy Volunteers Idiopathic Pulmonary Fibrosis Oxygen Blood pressure 030228 respiratory system Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart & Lung. 50:197-205 |
| ISSN: | 0147-9563 |
| Popis: | Background Hemodynamic response to supplemental oxygen in idiopathic pulmonary fibrosis (IPF) is still not well known. Objective To determine and compare the effect of low-flow acute supplemental oxygen on the hemodynamics of IPF patients and matched healthy subjects. Methods Descriptive and comparative study in 20 IPF-patients and 19 Control-subjects, (60-80 years old) breathing ambient air followed by acute nasal low-flow (3 L/min) supplemental oxygen. Non-invasive methods were used during the supine position to evaluate oxygen saturation, heart rate, stroke volume index, cardiac output index, total peripheral resistance and arterial blood pressure. Results Breathing ambient air, IPF (vs. Control) presented lower values in stroke volume index (38.7 [29.4–43.2] vs. 45.4 [38.4–50.9] mL•kg-1•m 2 ; p=0.009) and cardiac output index (2.484 [2.268 – 2.946] vs. 2.857 [2.628 – 3.054] L•min−1•m−2; p=0.028), with higher total peripheral resistance (1644 [1559–2076] vs. 1505 [1366–1784] dyne•s•cm−5; p=0.017). During supplemental oxygen (vs. ambient air), both groups increased oxygen saturation above 94% (p Conclusion Low-flow acute supplemental oxygen in IPF causes a meaningful decrement in cardiac output due to greater reduction in heart rate and increment in total peripheral resistance than matched healthy subjects. Knowing the hemodynamic profile of IPF patients may be helpful in determining their management with supplemental oxygen. |
| Databáze: | OpenAIRE |
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