Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier
| Autor: | Nataliya Mitina, L I Kоbyli nska, Alexander Zaichenko, B S Zіme nkovsky, Rostyslav Stoika, D. Ya. Havrylyuk, Roman Lesyk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male Sodium Potassium Iron chemistry.chemical_element Antineoplastic Agents 02 engineering and technology Polyethylene glycol 010402 general chemistry Kidney 01 natural sciences Biochemistry Chloride Nephrotoxicity Polyethylene Glycols lcsh:Biochemistry chemistry.chemical_compound Blood serum Chlorides medicine Animals Outbred Strains Toxicity Tests Acute Organic chemistry Animals Urea lcsh:QD415-436 Drug Carriers Chromatography Chemistry Kidney metabolism Polyynes Blood Proteins 021001 nanoscience & nanotechnology 0104 chemical sciences Nanostructures Rats Doxorubicin Creatinine Epoxy Compounds Methacrylates Thiazolidines Calcium 0210 nano-technology medicine.drug |
| Zdroj: | Ukrainian Biochemical Journal, Vol 88, Iss 1, Pp 51-60 (2016) |
| ISSN: | 2409-4943 |
| Popis: | The aim of this study was to compare the effect of new synthetic 4-thiazolidinone derivatives (potential anticancer compounds denoted as 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyethylene glycol-containing nanoscale polymeric carrier on the biochemical indicators of nephrotoxicity in blood serum of rats. The concentration of total protein, urea, creatinine, glucose, ions of sodium, potassium, calcium, iron and chloride was measured. It was found that after injection of the investigated compounds, the concentration of sodium cations and chloride anions in blood serum was increased compared with control (untreated animals). Doxorubicin’s injection was accompanied by a decrease in the concentration of iron cations. The concentration of total protein, urea and creatinine decreased under the influence of the studied compounds. Complexation of these аntineoplastic substances with a synthetic polymeric nanocarrier lowered the concentration of the investigated metabolites substantially compared to the effect of these compounds in free form. The normalization of concentration of total protein, urea and creatinine in blood serum of rats treated with complexes of the studied compounds with the polymeric carrier comparing with increased concentration of these indicators at the introduction of such compounds in free form was found. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|