Quantum Cascade Laser Based Infrared Spectroscopy: A New Paradigm for Protein Secondary Structure Measurement

Autor: Chunguang Jin, Amrish Patel, Jeremy Peters, Santosh Hodawadekar, Ravi Kalyanaraman
Rok vydání: 2022
Předmět:
Zdroj: Pharmaceutical Research.
ISSN: 1573-904X
0724-8741
DOI: 10.1007/s11095-022-03422-8
Popis: Mid-infrared spectroscopy is one of the major analytical techniques employed for measurements of protein structure in solution. Traditional Fourier Transform-Infrared (FT-IR) measurement is limited by its blackbody light source that is inherently spatially incoherent and has low optical power output. This limitation is pronounced when working with proteins in aqueous solutions. Strong absorbance of water in protein amide I region 1600-1700 cm
Databáze: OpenAIRE
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