Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival
| Autor: | Olatoyosi Odenike, Hongtao Liu, Andrew S. Artz, Usama Gergis, Stephanie Tsai, Sebastian Mayer, Tsiporah B. Shore, Parameswaran Hari, Melissa M. Cushing, Mei-Jie Zhang, Michael R. Bishop, Koen van Besien, Amittha Wickrema, Joanna Rhodes, Richard A. Larson, Sandra Korman, Lucy A. Godley, Wendy Stock |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Transplantation Conditioning Neutrophils medicine.medical_treatment Umbilical Cord Blood Stem Cell Graft vs Host Disease Hematopoietic stem cell transplantation Comorbidity Kaplan-Meier Estimate Umbilical cord Leukocyte Count 0302 clinical medicine HLA Antigens Recurrence Medicine Aged 80 and over Histocompatibility Testing Graft Survival Hematopoietic Stem Cell Transplantation Hematology Total body irradiation Middle Aged medicine.anatomical_structure surgical procedures operative Treatment Outcome 030220 oncology & carcinogenesis Hematologic Neoplasms Disease Progression Female Cord Blood Stem Cell Transplantation Unrelated Donors Adult medicine.medical_specialty endocrine system Urology Article 03 medical and health sciences Young Adult Humans Transplantation Homologous Mortality Aged business.industry Umbilical Cord Blood Transplantation Hematopoietic Stem Cells Surgery Transplantation Haplotypes business 030215 immunology |
| Zdroj: | Haematologica. 101(5) |
| ISSN: | 1592-8721 0094-3800 |
| Popis: | Umbilical cord blood stem cell transplants are commonly used in adults lacking HLA-identical donors. Delays in hematopoietic recovery contribute to mortality and morbidity. To hasten recovery, we used co-infusion of progenitor cells from a partially matched related donor and from an umbilical cord blood graft (haplo-cord transplant). Here we compared the outcomes of haplo-cord and double-cord transplants. A total of 97 adults underwent reduced intensity conditioning followed by haplo-cord transplant and 193 patients received reduced intensity conditioning followed by double umbilical cord blood transplantation. Patients in the haplo-cord group were more often from minority groups and had more advanced malignancy. Haplo-cord recipients received fludarabine-melphalan-anti-thymocyte globulin. Double umbilical cord blood recipients received fludarabine-cyclophosphamide and low-dose total body irradiation. In a multivariate analysis, haplo-cord had faster neutrophil (HR=1.42, P=0.007) and platelet (HR=2.54, P |
| Databáze: | OpenAIRE |
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