Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease
| Autor: | Laura D. Owlett, John A. Olschowka, Elizabeth Belcher, M. Kerry O'Banion, Dawling A. Dionisio-Santos, Jacqueline P. Williams |
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| Rok vydání: | 2020 |
| Předmět: |
Genetically modified mouse
Male Pathology medicine.medical_specialty 010504 meteorology & atmospheric sciences Amyloid Amyloid beta Health Toxicology and Mutagenesis Mice Transgenic tau Proteins Disease medicine.disease_cause 01 natural sciences Ionizing radiation Amyloid beta-Protein Precursor Mice Alzheimer Disease mental disorders 0103 physical sciences Gene expression medicine Presenilin-1 Animals Fear conditioning 010303 astronomy & astrophysics 0105 earth and related environmental sciences Radiation Amyloid beta-Peptides Ecology biology business.industry Astronomy and Astrophysics Agricultural and Biological Sciences (miscellaneous) biology.protein Female business Oxidative stress |
| Zdroj: | Life sciences in space research. 27 |
| ISSN: | 2214-5532 |
| Popis: | Space radiation is comprised of highly charged ions (HZE particles) and protons that are able to pass through matter and cause radiation-induced injury, including neuronal damage and degeneration, glial activation, and oxidative stress. Previous work demonstrated a worsening of Alzheimer's disease pathology in the APP/PS1 transgenic mouse model, however effects of space radiation on tau pathology have not been studied. To determine whether tau pathology is altered by HZE particle or proton irradiation, we exposed 3xTg mice, which acquire both amyloid plaque and tau pathology with age, to iron, silicon, or solar particle event (SPE) irradiation at 9 months of age and evaluated behavior and brain pathology at 16 months of age. We found no differences in performance in fear conditioning and novel object recognition tasks between groups of mice exposed to sham, iron (10 and 100 cGy), silicon (10 and 100 cGy), or solar particle event radiation (200 cGy), though female mice had higher freezing responses than males. 200 cGy SPE irradiated female mice had fewer plaques than sham-irradiated females but had no differences in tau pathology. Overall, females had worse amyloid and tau pathology at 16 months of age and demonstrated a reduced neuroinflammatory gene expression response to radiation. These findings uncover differences between mouse models following radiation injury and corroborate prior reports of sex differences within the 3xTg mouse model. |
| Databáze: | OpenAIRE |
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