Anxiolytic-like effect of a novel peptide isolated from the venom of the social wasp Synoeca surinama
| Autor: | Octavio L. Franco, Adolfo Carlos Barros de Souza, Flávia Maria Medeiros Gomes, Márcia Renata Mortari, Nelson G. Oliveira-Júnior, Cássia Karolina Paniago, Daniel Oliveira Freire, Marcos Robalinho Lima |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Elevated plus maze Venom Peptide Wasp Venoms Pharmacology Biology Toxicology Anxiolytic like 03 medical and health sciences 0302 clinical medicine medicine Animals Rats Wistar Pathological chemistry.chemical_classification Dose-Response Relationship Drug Rats 030104 developmental biology chemistry Anti-Anxiety Agents Anesthesia Anxiety Female medicine.symptom Peptides 030217 neurology & neurosurgery |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 122 |
| ISSN: | 1879-3150 |
| Popis: | Pathological anxiety is among the most common psychiatric illnesses, but current treatment is highly limited. In this study, we investigated the potential anxiolytic-like effects of a peptide isolated from Synoeca surinama venom. Rats treated with this peptide spent more time exploring the open arms of elevated plus maze, which indicates an anxiolytic-like profile for this peptide. This study is the first to show the pharmacological use of S. surinama venom in the treatment of anxiety. |
| Databáze: | OpenAIRE |
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