Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
| Autor: | G.I. de Zubicaray, Natalie T. Mills, Henry Völzke, N. van der Wee, A Block, Margaret J. Wright, D. Schoepf, Paul M. Thompson, Miguel E. Rentería, Neda Jahanshad, Hans-Jörgen Grabe, Beata R. Godlewska, Claus Normann, Nicholas G. Martin, Ilya M. Veer, Lachlan T. Strike, Baptiste Couvy-Duchesne, Nathan A. Gillespie, T.G.M. van Erp, Katrin Hegenscheid, Ian B. Hickie, Sean N. Hatton, Katharina Wittfeld, Helen Christensen, Derrek P. Hibar, Philip J. Cowen, Lianne Schmaal, Dick J. Veltman, Katie L. McMahon, Sarah E. Medland, Elisabeth Schramm, Henrik Walter, Knut Schnell, Carsten Konrad, Bartosz Zurowski, Jim Lagopoulos, B.W.J.H. Penninx |
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| Přispěvatelé: | Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Anatomy and neurosciences, APH - Mental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
epidemiology [Depressive Disorder Major] Poison control statistics & numerical data [Suicide] psychology [Depressive Disorder Major] methods [Magnetic Resonance Imaging] 0302 clinical medicine pathology [Brain] Risk Factors Prevalence Suicidal ideation education.field_of_study Brain Middle Aged Magnetic Resonance Imaging 3. Good health Suicide Psychiatry and Mental health Schizophrenia Brain size Major depressive disorder Original Article Female medicine.symptom methods [Neuroimaging] Psychology Clinical psychology Adult medicine.medical_specialty Population Neuroimaging diagnostic imaging [Depressive Disorder Major] Suicidal Ideation Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience medicine Humans Department Sport- und Gesundheitswissenschaften ddc:610 education Psychiatry diagnostic imaging [Brain] Biological Psychiatry Aged Depressive Disorder Major psychology [Suicide] medicine.disease 030227 psychiatry Mood disorders anatomy & histology [Brain] 030217 neurology & neurosurgery |
| Zdroj: | Translational Psychiatry, 7(5):e1116. Nature Publishing Group Renteria, ME; Schmaal, L; Hibar, DP; Couvy-Duchesne, B; Strike, LT; Mills, NT; et al.(2017). Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group. TRANSLATIONAL PSYCHIATRY, 7. doi: 10.1038/tp.2017.84. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6jg529fg Translational Psychiatry, 7 Rentería, M E, Schmaal, L, Hibar, D P, Couvy-Duchesne, B, Strike, L T, Mills, N T, De Zubicaray, G I, McMahon, K L, Medland, S E, Gillespie, N A, Hatton, S N, Lagopoulos, J, Veltman, D J, Van Der Wee, N, Van Erp, T G M, Wittfeld, K, Grabe, H J, Block, A, Hegenscheid, K, Völzke, H, Veer, I M, Walter, H, Schnell, K, Schramm, E, Normann, C, Schoepf, D, Konrad, C, Zurowski, B, Godlewska, B R, Cowen, P J, Penninx, B W J H, Jahanshad, N, Thompson, P M, Wright, M J, Martin, N G, Christensen, H, Hickie, I B & for the ENIGMA-Major Depressive Disorder Working Group 2017, ' Subcortical brain structure and suicidal behaviour in major depressive disorder : A meta-analysis from the ENIGMA-MDD working group ', Translational Psychiatry, vol. 7, no. 5, e1116 . https://doi.org/10.1038/tp.2017.84 Translational Psychiatry 7(5), e1116-e1116 (2017). doi:10.1038/tp.2017.84 Translational Psychiatry |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/tp.2017.84. |
| Popis: | The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n = 3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N = 451) vs healthy controls (N = 1996) or MDD patients with no suicidal symptoms (N = 650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P = 4.12 × 10 - 3) or a 2.87% smaller volume compared with controls (Cohen's d = - 0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P = 0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments. |
| Databáze: | OpenAIRE |
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