Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis

Autor: Luigi Russo, Domenico Russo, Monica Lamberti, Andrea Pota, Bernadette Scognamiglio, Yuri Battaglia, Angelo Carlomagno, Salvatore Corrao, Nicoletta Pezone, Maurizio Sacco, Michele Andreucci, Antonella Caiazza
Přispěvatelé: Russo D, Corrao, S, Battaglia, Y, Andreucci, M, Caiazza, A, Carlomagno, A, Lamberti, M, Pezone, N, Pota, A, Russo, L, Sacco, M, Scognamiglio, B, Russo, D, Lamberti, Monica, Scognamiglio, B., Russo, Domenico, Salvatore, Corrao, Yuri, Battaglia, Michele, Andreucci, Antonella, Caiazza, Angelo, Carlomagno, Monica, Lamberti, Nicoletta, Pezone, Andrea, Pota, Luigi, Russo, Maurizio, Sacco, Bernadette, Scognamiglio
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
Nephrology
medicine.medical_specialty
Settore MED/09 - Medicina Interna
medicine.medical_treatment
Myocardial Infarction
cardiovascular events
chronic kidney disease
coronary calcification
Coronary Artery Disease
Kaplan-Meier Estimate
Cohort Studies
Coronary artery disease
cardiovascular events
Risk Factors
Calcinosis
Internal medicine
medicine
Humans
Myocardial infarction
Renal Insufficiency
Chronic
Dialysis
Aged
Settore MED/14 - Nefrologia
business.industry
Hazard ratio
coronary calcification
Middle Aged
Prognosis
medicine.disease
cardiovascular event
Settore MED/45 - Scienze Infermieristiche Generali
Cliniche E Pediatriche
Settore MED/11 - Malattie Dell'Apparato Cardiovascolare
Surgery
Disease Progression
Cardiology
Female
Original Article
business
chronic kidney disease
Kidney disease
Calcification
Zdroj: Kidney International
Popis: We tested for the presence of coronary calcifications in patients with chronic renal disease not on dialysis and studied its progression in 181 consecutive non-dialyzed patients who were followed for a median of 745 days. Coronary calcifications (calcium score) were tallied in Agatston units by computed tomography, and the patients were stratified into two groups by their baseline calcium score (100 U or less and over 100 U). Survival was measured by baseline calcium score and its progression. Cardiac death and myocardial infarction occurred in 29 patients and were significantly more frequent in those patients with calcium scores over 100 U (hazard ratio of 4.11). With a calcium score of 100 U or less, the hazard ratio for cardiac events was 0.41 and 3.26 in patients with absent and accelerated progression, respectively. Thus, in non-dialyzed patients, the extent of coronary calcifications was associated to cardiac events, and progression was an independent predictive factor of cardiac events mainly in less calcified patients. Hence, assessment of coronary calcifications and progression might be useful for earlier management of risk factors and guiding decisions for prevention of cardiac events in this patient population.
Databáze: OpenAIRE
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