Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind-like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases
| Autor: | Robert O. Greer, Jeffrey Eskendri, Marileila Varella-Garcia, Aline Murakami-Walter, Moni Ahmadian, Paul D. Freedman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty H&E stain In situ hybridization Mandible Biology Jaw neoplasm Article Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Glandular odontogenic cyst medicine Biomarkers Tumor Maxilla Humans Cyst In Situ Hybridization Fluorescence Aged Gene Rearrangement Goblet cell Nuclear Proteins Epithelial Cells 030206 dentistry Gene rearrangement Middle Aged medicine.disease Jaw Neoplasms DNA-Binding Proteins Radiography medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Odontogenic Cysts Trans-Activators Periodontics Keratins Carcinoma Mucoepidermoid Female Oral Surgery Neoplasm Recurrence Local Jaw Diseases Transcription Factors |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 47(2) |
| ISSN: | 1600-0714 |
| Popis: | Background Glandular odontogenic cyst (GOC) demonstrates a significant predilection toward localized biologic aggressiveness and recurrence. GOC shares certain histopathologic features with intraosseous mucoepidermoid carcinoma (IMEC). The current investigation evaluates a group of recurrent, biologically aggressive GOCs to determine if any cases demonstrated unique histologic features or Mastermind – like2 (MAML2) rearrangements common to IMEC. Methods Microscopic slides from eleven previously diagnosed GOGs were stained with hematoxylin and eosin and assessed by two study participants for ten classic histopathologic features required to establish a diagnosis of GOC. Cases were evaluated utilizing break-apart fluorescent in situ hybridization (FISH) analysis for the presence of MAML2 gene rearrangements. Clinical and demographic data on all patients were recorded. Results The mean age for patients included in the study was 55.27 years with a range of 36 to 72 years. The most common presenting symptom was a jaw expansion and all cysts presented initially as a unilocular or multilocular radiolucency. CYSTS displayed a minimum of 6 of 10 histologic parameters necessary for a diagnosis of GOC. One case demonstrated MAML2 rearrangements by FISH. That case also showed marked ciliation of cyst lining epithelial cells and extensive mucous secreting goblet cell proliferation. Conclusion Findings in the current study are in concert with previous investigations, and although this study finds ONLY LIMITED molecular evidence to support the premise that recurrent biologically aggressive GOCs are a precursor to IMEC, detection of MAML2 rearrangements in one case suggests that such a theoretic transition, while rare, is possible. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text